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Scientists Will Begin Testing Novel Malaria Vaccine in Monkeys


The first vaccine with enough weapons to have a real chance against malaria is about to be tested in monkeys, scientists announced Monday.

The new vaccine has shown strong promise in the laboratory and will be tried in monkeys in March, said molecular biologist Altaf Lal, at the Centers for Disease Control and Prevention in Atlanta. If it works, human testing will not be far off.

"The unique feature is that we're targeting different stages" in the malaria parasite's migration through the human body, Lal said. "And at each stage we're targeting several different parts" of the parasite's anatomy.

Vaccines typically work by alerting the body's main line of defense, the immune system, to the danger of a potential infection. Once alerted, the immune defense system remains armed and ready for war if a real infection arrives.

This standard vaccine approach works well against measles, smallpox and many other infections. But it has not been very effective against malaria, because the malaria organism keeps changing its uniform.

Now Lal and nine of his colleagues at the Centers for Disease Control and Prevention, the National Institute of Immunology in India, the Naval Medical Research Institute in Maryland, Case Western Reserve University in Ohio and Johns Hopkins University in Maryland have engineered this vaccine to hit all stages of the infection.

Hillary Would Be Terrific In The Senate'According to President

The Washington Post

If first lady Hillary Rodham Clinton is seriously thinking about running for the U.S. Senate from New York, she isn't saying so yet. But at least one well-placed source suggested Monday that she is taking a hard look at it.

President Clinton told reporters during a brief visit to Mexico that his wife "would be terrific in the Senate" and that he would support her "enthusiastically" if she chooses to run. While many supporters have been lobbying her to run, he added, she needs a chance to reflect before making a decision.

"She'd be great if she did it," he said at a photo opportunity with Mexican President Ernesto Zedillo. "But she hasn't had anything like the requisite amount of time to talk to people and to assess it, and I'm sure that everyone will understand and appreciate it."

His comments were the most explicit suggestion to date that the Hillary Clinton-for-Senate campaign might be more than a pipe dream among Empire State Democrats seeking a strong candidate to take on New York Mayor Rudolph Giuliani (R) for the seat being vacated by Daniel Patrick Moynihan (D) in 2000.

That Hillary Clinton has not quashed the talk has encouraged many to assume she is interested. Neither of the Clintons had commented publicly on the idea before Monday and the president's words indicated that he, at least, appeared to be taking it seriously.

Iraqis Fail Mission In Turkey

the Los Angeles Times
ANKARA, Turkey

Hoping to drive a wedge between the United States and a key ally, Iraqi Deputy Prime Minister Tarik Aziz instead came away empty-handed from a meeting here Monday with Turkish Prime Minister Bulent Ecevit.

Emerging from nearly three hours of talks with the new leftist premier, Aziz said, "We discussed our legitimate concerns in a friendly manner." In a predictable swipe at the United States, he added that "we have to deal with our bilateral relations in a direct straightforward manner, and we shall not let foreigners to interfere in those relations."

But even as the Iraqi official was meeting with Ecevit, U.S. warplanes stationed at a NATO base in southern Turkey attacked Iraqi air defenses in northern Iraq. And shortly after, Ecevit justified the attacks, saying they had been carried out in "self-defense." It was the first time Ecevit has publicly condoned U.S. action against Iraq.

A senior Turkish official close to Monday's talks, who spoke on condition of anonymity, said that Aziz had demanded that Ecevit scrap the mandate under which U.S. and British warplanes stationed at the Incirlik base patrol the skies over Kurdish-controlled northern Iraq. The so-called "Kurdish safe haven" there was established at the end of the 1991 Persian Gulf War in the aftermath of the Kurds' failed rebellion against Baghdad.

"The answer he got was a big no," the official said.